Structures of filaments from Pick’s disease reveal a novel tau protein fold

The ordered assembly of tau protein into abnormal filamentous inclusions underlies many human neurodegenerative diseases(1). Tau assemblies appear to spread through specific neural networks in each disease(2), with short filaments having the greatest seeding activity(3). The abundance of tau inclusi...

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Bibliographic Details
Published in:Nature
Main Authors: Falcon, Benjamin, Zhang, Wenjuan, Murzin, Alexey G., Murshudov, Garib, Garringer, Holly J., Vidal, Ruben, Crowther, R. Anthony, Ghetti, Bernardino, Scheres, Sjors H.W., Goedert, Michel
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204212/
https://ncbi.nlm.nih.gov/pubmed/30158706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0454-y
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