Cryo-EM structures of tau filaments from Alzheimer’s disease with PET ligand APN-1607

Tau and Aβ assemblies of Alzheimer’s disease (AD) can be visualized in living subjects using positron emission tomography (PET). Tau assemblies comprise paired helical and straight filaments (PHFs and SFs). APN-1607 (PM-PBB3) is a recently described PET ligand for AD and other tau proteinopathies. S...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Acta Neuropathol
Main Authors: Shi, Yang, Murzin, Alexey G., Falcon, Benjamin, Epstein, Alexander, Machin, Jonathan, Tempest, Paul, Newell, Kathy L., Vidal, Ruben, Garringer, Holly J., Sahara, Naruhiko, Higuchi, Makoto, Ghetti, Bernardino, Jang, Ming-Kuei, Scheres, Sjors H. W., Goedert, Michel
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2021
Teme:
Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8043864/
https://ncbi.nlm.nih.gov/pubmed/33723967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-021-02294-3
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