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Structure-based drug design of phenazopyridine derivatives as inhibitors of Rev1 interactions in translesion synthesis
Rev1 is a protein scaffold of the translesion synthesis (TLS) pathway, which employs low-fidelity DNA polymerases for replication of damaged DNA. The TLS pathway helps cancers tolerate DNA damage induced by genotoxic chemotherapy, and increases mutagenesis in tumors, accelerating the onset of chemor...
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| Udgivet i: | ChemMedChem |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8035318/ https://ncbi.nlm.nih.gov/pubmed/33314657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000893 |
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