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Structure-based drug design of phenazopyridine derivatives as inhibitors of Rev1 interactions in translesion synthesis

Rev1 is a protein scaffold of the translesion synthesis (TLS) pathway, which employs low-fidelity DNA polymerases for replication of damaged DNA. The TLS pathway helps cancers tolerate DNA damage induced by genotoxic chemotherapy, and increases mutagenesis in tumors, accelerating the onset of chemor...

詳細記述

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書誌詳細
出版年:ChemMedChem
主要な著者: McPherson, Kerry Silva, Zaino, Angela M., Dash, Radha C., Rizzo, Alessandro A., Li, Yunfeng, Hao, Bing, Bezsonova, Irina, Hadden, M. Kyle, Korzhnev, Dmitry M.
フォーマット: Artigo
言語:Inglês
出版事項: 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8035318/
https://ncbi.nlm.nih.gov/pubmed/33314657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000893
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