Structure-based drug design of phenazopyridine derivatives as inhibitors of Rev1 interactions in translesion synthesis

Rev1 is a protein scaffold of the translesion synthesis (TLS) pathway, which employs low-fidelity DNA polymerases for replication of damaged DNA. The TLS pathway helps cancers tolerate DNA damage induced by genotoxic chemotherapy, and increases mutagenesis in tumors, accelerating the onset of chemor...

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Publicado no:ChemMedChem
Main Authors: McPherson, Kerry Silva, Zaino, Angela M., Dash, Radha C., Rizzo, Alessandro A., Li, Yunfeng, Hao, Bing, Bezsonova, Irina, Hadden, M. Kyle, Korzhnev, Dmitry M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8035318/
https://ncbi.nlm.nih.gov/pubmed/33314657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000893
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