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Structure-based drug design of phenazopyridine derivatives as inhibitors of Rev1 interactions in translesion synthesis
Rev1 is a protein scaffold of the translesion synthesis (TLS) pathway, which employs low-fidelity DNA polymerases for replication of damaged DNA. The TLS pathway helps cancers tolerate DNA damage induced by genotoxic chemotherapy, and increases mutagenesis in tumors, accelerating the onset of chemor...
Kaydedildi:
| Yayımlandı: | ChemMedChem |
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| Asıl Yazarlar: | , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2021
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8035318/ https://ncbi.nlm.nih.gov/pubmed/33314657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000893 |
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