Wird geladen...
Identification of small molecule translesion synthesis inhibitors that target the Rev1-CT/RIR protein-protein interaction
Translesion synthesis (TLS) is an important mechanism through which proliferating cells tolerate DNA damage during replication. The mutagenic Rev1/Polζ-dependent branch of TLS helps cancer cells survive first-line genotoxic chemotherapy and introduces mutations that can contribute to the acquired re...
Gespeichert in:
| Veröffentlicht in: | ACS Chem Biol |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2017
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5992617/ https://ncbi.nlm.nih.gov/pubmed/28541665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b01144 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|