Caricamento...

Identification of small molecule translesion synthesis inhibitors that target the Rev1-CT/RIR protein-protein interaction

Translesion synthesis (TLS) is an important mechanism through which proliferating cells tolerate DNA damage during replication. The mutagenic Rev1/Polζ-dependent branch of TLS helps cancer cells survive first-line genotoxic chemotherapy and introduces mutations that can contribute to the acquired re...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:ACS Chem Biol
Autori principali: Sail, Vibhavari, Rizzo, Alessandro A., Chatterjee, Nimrat, Dash, Radha C., Ozen, Zuleyha, Walker, Graham C., Korzhnev, Dmitry M., Hadden, M. Kyle
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992617/
https://ncbi.nlm.nih.gov/pubmed/28541665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b01144
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !