Identification of small molecule translesion synthesis inhibitors that target the Rev1-CT/RIR protein-protein interaction

Translesion synthesis (TLS) is an important mechanism through which proliferating cells tolerate DNA damage during replication. The mutagenic Rev1/Polζ-dependent branch of TLS helps cancer cells survive first-line genotoxic chemotherapy and introduces mutations that can contribute to the acquired re...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Sail, Vibhavari, Rizzo, Alessandro A., Chatterjee, Nimrat, Dash, Radha C., Ozen, Zuleyha, Walker, Graham C., Korzhnev, Dmitry M., Hadden, M. Kyle
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992617/
https://ncbi.nlm.nih.gov/pubmed/28541665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b01144
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