Virtual Pharmacophore Screening Identifies Small Molecule Inhibitors of the Rev1-CT/RIR Protein-Protein Interaction

Translesion synthesis (TLS) has emerged as a mechanism through which several forms of cancer develop acquired resistance to first-line genotoxic chemotherapies by allowing replication to continue in the presence of damaged DNA. Small molecules that inhibit TLS hold promise as a novel class of anti-c...

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Publicado no:ChemMedChem
Main Authors: Dash, Radha C., Ozen, Zuleyha, McCarthy, Kaitlyn R., Chatterjee, Nimrat, Harris, Cynthia A., Rizzo, Alessandro A., Walker, Graham C., Korzhnev, Dmitry M., Hadden, M. Kyle
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726565/
https://ncbi.nlm.nih.gov/pubmed/31361935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201900307
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