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Therapeutic Opportunities of Targeting Allosteric Binding Sites on the Calcium-Sensing Receptor

[Image: see text] The CaSR is a class C G protein-coupled receptor (GPCR) that acts as a multimodal chemosensor to maintain diverse homeostatic functions. The CaSR is a clinical therapeutic target in hyperparathyroidism and has emerged as a putative target in several other diseases. These include hy...

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Bibliographische Detailangaben
Veröffentlicht in:ACS Pharmacol Transl Sci
Hauptverfasser: Diao, Jiayin, DeBono, Aaron, Josephs, Tracy M., Bourke, Jane E., Capuano, Ben, Gregory, Karen J., Leach, Katie
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2021
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8033781/
https://ncbi.nlm.nih.gov/pubmed/33860192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.1c00046
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