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RNA toxicity induced by expanded CAG repeats in Huntington's disease

Huntington's disease (HD) belongs to the group of inherited polyglutamine (PolyQ) diseases caused by an expanded CAG repeat in the coding region of the Huntingtin (HTT) gene that results in an elongated polyQ stretch. Abnormal function and aggregation of the mutant protein has been typically de...

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Detalles Bibliográficos
Publicado en:Brain Pathol
Autor Principal: Martí, Eulàlia
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8029335/
https://ncbi.nlm.nih.gov/pubmed/27529325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12427
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