FAN1 modifies Huntington’s disease progression by stabilizing the expanded HTT CAG repeat

Huntington’s disease (HD) is an inherited neurodegenerative disease caused by an expanded CAG repeat in the huntingtin (HTT) gene. CAG repeat length explains around half of the variation in age at onset (AAO) but genetic variation elsewhere in the genome accounts for a significant proportion of the...

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Dettagli Bibliografici
Pubblicato in:Hum Mol Genet
Autori principali: Goold, Robert, Flower, Michael, Moss, Davina Hensman, Medway, Chris, Wood-Kaczmar, Alison, Andre, Ralph, Farshim, Pamela, Bates, Gill P, Holmans, Peter, Jones, Lesley, Tabrizi, Sarah J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
Soggetti:
General Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360275/
https://ncbi.nlm.nih.gov/pubmed/30358836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy375
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