FAN1 modifies Huntington’s disease progression by stabilizing the expanded HTT CAG repeat

Huntington’s disease (HD) is an inherited neurodegenerative disease caused by an expanded CAG repeat in the huntingtin (HTT) gene. CAG repeat length explains around half of the variation in age at onset (AAO) but genetic variation elsewhere in the genome accounts for a significant proportion of the...

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Bibliografski detalji
Izdano u:Hum Mol Genet
Glavni autori: Goold, Robert, Flower, Michael, Moss, Davina Hensman, Medway, Chris, Wood-Kaczmar, Alison, Andre, Ralph, Farshim, Pamela, Bates, Gill P, Holmans, Peter, Jones, Lesley, Tabrizi, Sarah J
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
General Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6360275/
https://ncbi.nlm.nih.gov/pubmed/30358836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy375
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