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Reduction of Huntington’s Disease RNA Foci by CAG Repeat-Targeting Reagents
In several human polyglutamine diseases caused by expansions of CAG repeats in the coding sequence of single genes, mutant transcripts are detained in nuclear RNA foci. In polyglutamine disorders, unlike other repeat-associated diseases, both RNA and proteins exert pathogenic effects; therefore, dec...
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| Publié dans: | Front Cell Neurosci |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Frontiers Media S.A.
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5368221/ https://ncbi.nlm.nih.gov/pubmed/28400719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2017.00082 |
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