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Reduction of Huntington’s Disease RNA Foci by CAG Repeat-Targeting Reagents

In several human polyglutamine diseases caused by expansions of CAG repeats in the coding sequence of single genes, mutant transcripts are detained in nuclear RNA foci. In polyglutamine disorders, unlike other repeat-associated diseases, both RNA and proteins exert pathogenic effects; therefore, dec...

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Bibliografische gegevens
Gepubliceerd in:Front Cell Neurosci
Hoofdauteurs: Urbanek, Martyna O., Fiszer, Agnieszka, Krzyzosiak, Wlodzimierz J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368221/
https://ncbi.nlm.nih.gov/pubmed/28400719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2017.00082
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