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Reduction of Huntington’s Disease RNA Foci by CAG Repeat-Targeting Reagents

In several human polyglutamine diseases caused by expansions of CAG repeats in the coding sequence of single genes, mutant transcripts are detained in nuclear RNA foci. In polyglutamine disorders, unlike other repeat-associated diseases, both RNA and proteins exert pathogenic effects; therefore, dec...

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Detalles Bibliográficos
Publicado en:Front Cell Neurosci
Main Authors: Urbanek, Martyna O., Fiszer, Agnieszka, Krzyzosiak, Wlodzimierz J.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5368221/
https://ncbi.nlm.nih.gov/pubmed/28400719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2017.00082
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