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Inhibition of mutant huntingtin expression by RNA duplex targeting expanded CAG repeats

The specific silencing of the gene of interest is the major objective of RNA interference technology; therefore, unique sequences but not abundant sequence repeats are targeted by silencing reagents. Here, we describe the targeting of expanded CAG repeats that occur in transcripts derived from the m...

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Библиографические подробности
Главные авторы: Fiszer, Agnieszka, Mykowska, Agnieszka, Krzyzosiak, Wlodzimierz J.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3141264/
https://ncbi.nlm.nih.gov/pubmed/21427085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr156
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