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Self-duplexing CUG repeats selectively inhibit mutant huntingtin expression
Huntington’s disease (HD) is a neurodegenerative genetic disorder caused by the expansion of the CAG repeat in the translated sequence of the HTT gene. This expansion generates a mutant huntingtin protein that contains an abnormally elongated polyglutamine tract, which, together with mutant transcri...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3905887/ https://ncbi.nlm.nih.gov/pubmed/24038471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt825 |
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