Cargando...

Self-duplexing CUG repeats selectively inhibit mutant huntingtin expression

Huntington’s disease (HD) is a neurodegenerative genetic disorder caused by the expansion of the CAG repeat in the translated sequence of the HTT gene. This expansion generates a mutant huntingtin protein that contains an abnormally elongated polyglutamine tract, which, together with mutant transcri...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Fiszer, Agnieszka, Olejniczak, Marta, Galka-Marciniak, Paulina, Mykowska, Agnieszka, Krzyzosiak, Wlodzimierz J.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905887/
https://ncbi.nlm.nih.gov/pubmed/24038471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt825
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!