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CAG repeats mimic CUG repeats in the misregulation of alternative splicing
Mutant transcripts containing expanded CUG repeats in the untranslated region are a pathogenic factor in myotonic dystrophy type 1 (DM1). The mutant RNA sequesters the muscleblind-like 1 (MBNL1) splicing factor and causes misregulation of the alternative splicing of multiple genes that are linked to...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3203611/ https://ncbi.nlm.nih.gov/pubmed/21795378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr608 |
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