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CAG repeats mimic CUG repeats in the misregulation of alternative splicing

Mutant transcripts containing expanded CUG repeats in the untranslated region are a pathogenic factor in myotonic dystrophy type 1 (DM1). The mutant RNA sequesters the muscleblind-like 1 (MBNL1) splicing factor and causes misregulation of the alternative splicing of multiple genes that are linked to...

詳細記述

保存先:
書誌詳細
主要な著者: Mykowska, Agnieszka, Sobczak, Krzysztof, Wojciechowska, Marzena, Kozlowski, Piotr, Krzyzosiak, Wlodzimierz J.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2011
主題:
RNA
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203611/
https://ncbi.nlm.nih.gov/pubmed/21795378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr608
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