RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disorders

Repeat-associated disorders caused by expansions of short sequences have been classified as coding and noncoding and are thought to be caused by protein gain-of-function and RNA gain-of-function mechanisms, respectively. The boundary between such classifications has recently been blurred by the disc...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Wojciechowska, Marzena, Olejniczak, Marta, Galka-Marciniak, Paulina, Jazurek, Magdalena, Krzyzosiak, Wlodzimierz J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231732/
https://ncbi.nlm.nih.gov/pubmed/25217582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku794
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