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Mutant CAG Repeats Effectively Targeted by RNA Interference in SCA7 Cells
Spinocerebellar ataxia type 7 (SCA7) is a human neurodegenerative polyglutamine (polyQ) disease caused by a CAG repeat expansion in the open reading frame of the ATXN7 gene. The allele-selective silencing of mutant transcripts using a repeat-targeting strategy has previously been used for several po...
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| Publicado no: | Genes (Basel) |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5192508/ https://ncbi.nlm.nih.gov/pubmed/27999335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes7120132 |
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