Atomic resolution structure of CAG RNA repeats: structural insights and implications for the trinucleotide repeat expansion diseases

CAG repeats occur predominantly in the coding regions of human genes, which suggests their functional importance. In some genes, these sequences can undergo pathogenic expansions leading to neurodegenerative polyglutamine (poly-Q) diseases. The mutant transcripts containing expanded CAG repeats poss...

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Bibliografiska uppgifter
Huvudupphovsmän: Kiliszek, Agnieszka, Kierzek, Ryszard, Krzyzosiak, Wlodzimierz J., Rypniewski, Wojciech
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2010
Ämnen:
Structural Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3001072/
https://ncbi.nlm.nih.gov/pubmed/20702420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq700
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