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Reduction of Huntington’s Disease RNA Foci by CAG Repeat-Targeting Reagents
In several human polyglutamine diseases caused by expansions of CAG repeats in the coding sequence of single genes, mutant transcripts are detained in nuclear RNA foci. In polyglutamine disorders, unlike other repeat-associated diseases, both RNA and proteins exert pathogenic effects; therefore, dec...
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| 出版年: | Front Cell Neurosci |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Frontiers Media S.A.
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5368221/ https://ncbi.nlm.nih.gov/pubmed/28400719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2017.00082 |
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