Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma

PTEN is one of the most frequently altered tumor suppressor genes in malignant tumors. The dominant-negative effect of PTEN alteration suggests that the aberrant function of PTEN mutation might be more disastrous than deletion, the most frequent genomic event in glioblastoma (GBM). This study aimed...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Choi, Seung Won, Lee, Yeri, Shin, Kayoung, Koo, Harim, Kim, Donggeon, Sa, Jason K., Cho, Hee Jin, Shin, Hye-mi, Lee, Se Jeong, Kim, Hyunho, Chung, Seok, Shin, Jihye, Lee, Cheolju, Nam, Do-Hyun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8027895/
https://ncbi.nlm.nih.gov/pubmed/33828082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03657-0
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