CBIO-04. MUTATION-SPECIFIC NON-CANONICAL PATHWAY OF PTEN AS A DISTINCT THERAPEUTIC TARGET FOR GLIOBLASTOMA

The dominant-negative effect of PTEN mutation has been described previously, suggesting that aberrant gain of function attributed to mutation might be more disastrous than deletion in respect to malignant potential. In present study, we explored the functional implications of hot spot mutations of P...

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Publicado en:Neuro Oncol
Autores principales: Won Choi, Seung, Lee, Yeri, Shin, Kayoung, Kim, Donggeon, Lee, Se Jeong, Kim, Hyunho, Chung, Seok, Shin, Jihye, Lee, Cheolju, Nam, Do-Hyun
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Cell Biology (Cell Cycle Regulation, DNA Repair/Modulation)
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650368/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.064
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