CBIO-04. MUTATION-SPECIFIC NON-CANONICAL PATHWAY OF PTEN AS A DISTINCT THERAPEUTIC TARGET FOR GLIOBLASTOMA

The dominant-negative effect of PTEN mutation has been described previously, suggesting that aberrant gain of function attributed to mutation might be more disastrous than deletion in respect to malignant potential. In present study, we explored the functional implications of hot spot mutations of P...

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Detaylı Bibliyografya
Yayımlandı:Neuro Oncol
Asıl Yazarlar: Won Choi, Seung, Lee, Yeri, Shin, Kayoung, Kim, Donggeon, Lee, Se Jeong, Kim, Hyunho, Chung, Seok, Shin, Jihye, Lee, Cheolju, Nam, Do-Hyun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2020
Konular:
Cell Biology (Cell Cycle Regulation, DNA Repair/Modulation)
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7650368/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.064
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