Isoform- and phosphorylation-specific multiplexed quantitative pharmacodynamics of drugs targeting PI3K and MAPK signaling in xenograft models and clinical biopsies

Ras/Raf/MEK/ERK (MAPK) and PI3K/AKT signaling pathways influence several cell functions involved in oncogenesis, making them attractive drug targets. We describe a novel multiplex immunoassay to quantitate isoform-specific phosphorylation of proteins in the PI3K/AKT and MAPK pathways as a tool to as...

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Publicado no:Mol Cancer Ther
Main Authors: Herrick, William G., Kilpatrick, Casey L., Hollingshead, Melinda G., Esposito, Dominic, Coyne, Geraldine O’Sullivan, Gross, Andrea M., Johnson, Barry C., Chen, Alice P., Widemann, Brigitte C., Doroshow, James H., Parchment, Ralph E., Srivastava, Apurva K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026683/
https://ncbi.nlm.nih.gov/pubmed/33536190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0566
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