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Effect of a Smac Mimetic (TL32711, Birinapant) on the Apoptotic Program and Apoptosis Biomarkers Examined with Validated Multiplex Immunoassays Fit for Clinical Use

PURPOSE: To support clinical pharmacodynamic evaluation of the Smac mimetic TL32711 (birinapant) and other apoptosis-targeting drugs, we describe the development, validation, and application of novel immunoassays for 15 cytosolic and membrane-associated proteins indicative of the induction, onset, a...

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書誌詳細
出版年:Clin Cancer Res
主要な著者: Srivastava, Apurva K., Jaganathan, Soumya, Stephen, Laurie, Hollingshead, Melinda G., Layhee, Adam, Damour, Eric, Govindharajulu, Jeevan Prasaad, Donohue, Jennifer, Esposito, Dominic, Mapes, James P., Kinders, Robert J., Takebe, Naoko, Tomaszewski, Joseph E., Kummar, Shivaani, Doroshow, James H., Parchment, Ralph E.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755826/
https://ncbi.nlm.nih.gov/pubmed/26446940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-3156
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