Effect of a Smac Mimetic (TL32711, Birinapant) on the Apoptotic Program and Apoptosis Biomarkers Examined with Validated Multiplex Immunoassays Fit for Clinical Use

PURPOSE: To support clinical pharmacodynamic evaluation of the Smac mimetic TL32711 (birinapant) and other apoptosis-targeting drugs, we describe the development, validation, and application of novel immunoassays for 15 cytosolic and membrane-associated proteins indicative of the induction, onset, a...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Srivastava, Apurva K., Jaganathan, Soumya, Stephen, Laurie, Hollingshead, Melinda G., Layhee, Adam, Damour, Eric, Govindharajulu, Jeevan Prasaad, Donohue, Jennifer, Esposito, Dominic, Mapes, James P., Kinders, Robert J., Takebe, Naoko, Tomaszewski, Joseph E., Kummar, Shivaani, Doroshow, James H., Parchment, Ralph E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755826/
https://ncbi.nlm.nih.gov/pubmed/26446940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-3156
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