PDLIM2 repression by ROS in alveolar macrophages promotes lung tumorigenesis

One of the most fundamental and challenging questions in the field of cancer is how immunity is transformed from tumor immunosurveillance to tumor-promoting inflammation. Here, we identified the tumor suppressor PDZ-LIM domain–containing protein 2 (PDLIM2) as a checkpoint of alveolar macrophages (AM...

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Podrobná bibliografie
Vydáno v:JCI Insight
Hlavní autoři: Li, Liwen, Sun, Fan, Han, Lei, Liu, Xujie, Xiao, Yadong, Gregory, Alyssa D., Shapiro, Steven D., Xiao, Gutian, Qu, Zhaoxia
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8021114/
https://ncbi.nlm.nih.gov/pubmed/33539325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.144394
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