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PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation

The mechanisms by which the human T-cell leukemia virus type I (HTLV-I) Tax oncoprotein deregulates cellular signaling for oncogenesis have been extensively studied, but how Tax itself is regulated remains largely unknown. Here we report that Tax was negatively regulated by PDLIM2, which promoted Ta...

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Detalhes bibliográficos
Main Authors: Yan, Pengrong, Fu, Jing, Qu, Zhaoxia, Li, Shirong, Tanaka, Takashi, Grusby, Michael J., Xiao, Gutian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2676091/
https://ncbi.nlm.nih.gov/pubmed/19131544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-10-185660
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