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PDLIM2 repression by ROS in alveolar macrophages promotes lung tumorigenesis

One of the most fundamental and challenging questions in the field of cancer is how immunity is transformed from tumor immunosurveillance to tumor-promoting inflammation. Here, we identified the tumor suppressor PDZ-LIM domain–containing protein 2 (PDLIM2) as a checkpoint of alveolar macrophages (AM...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Li, Liwen, Sun, Fan, Han, Lei, Liu, Xujie, Xiao, Yadong, Gregory, Alyssa D., Shapiro, Steven D., Xiao, Gutian, Qu, Zhaoxia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8021114/
https://ncbi.nlm.nih.gov/pubmed/33539325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.144394
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