PDLIM2 repression by ROS in alveolar macrophages promotes lung tumorigenesis

One of the most fundamental and challenging questions in the field of cancer is how immunity is transformed from tumor immunosurveillance to tumor-promoting inflammation. Here, we identified the tumor suppressor PDZ-LIM domain–containing protein 2 (PDLIM2) as a checkpoint of alveolar macrophages (AM...

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Detalles Bibliográficos
Publicado en:JCI Insight
Main Authors: Li, Liwen, Sun, Fan, Han, Lei, Liu, Xujie, Xiao, Yadong, Gregory, Alyssa D., Shapiro, Steven D., Xiao, Gutian, Qu, Zhaoxia
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8021114/
https://ncbi.nlm.nih.gov/pubmed/33539325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.144394
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