PDLIM2 repression by ROS in alveolar macrophages promotes lung tumorigenesis

One of the most fundamental and challenging questions in the field of cancer is how immunity is transformed from tumor immunosurveillance to tumor-promoting inflammation. Here, we identified the tumor suppressor PDZ-LIM domain–containing protein 2 (PDLIM2) as a checkpoint of alveolar macrophages (AM...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JCI Insight
Prif Awduron: Li, Liwen, Sun, Fan, Han, Lei, Liu, Xujie, Xiao, Yadong, Gregory, Alyssa D., Shapiro, Steven D., Xiao, Gutian, Qu, Zhaoxia
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2021
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8021114/
https://ncbi.nlm.nih.gov/pubmed/33539325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.144394
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