The structure of the native cardiac thin filament at systolic Ca(2+) levels

Every heartbeat relies on cyclical interactions between myosin thick and actin thin filaments orchestrated by rising and falling Ca(2+) levels. Thin filaments are comprised of two actin strands, each harboring equally separated troponin complexes, which bind Ca(2+) to move tropomyosin cables away fr...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Risi, Cristina M., Pepper, Ian, Belknap, Betty, Landim-Vieira, Maicon, White, Howard D., Dryden, Kelly, Pinto, Jose R., Chase, P. Bryant, Galkin, Vitold E.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2021
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020778/
https://ncbi.nlm.nih.gov/pubmed/33753506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024288118
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