Gene Transfer in Adeno-Associated Virus Seropositive Rhesus Macaques Following Rapamycin Treatment and Subcutaneous Delivery of AAV6, but Not Retargeted AAV6 Vectors

Adeno-associated virus (AAV) vectors such as AAV6, which shows tropism for primary human CD4(+) T cells in vitro, are being explored for delivery of anti-HIV therapeutic modalities in vivo. However, pre-existing immunity and sequestration in nontarget organs can significantly hinder their performanc...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Hum Gene Ther
المؤلفون الرئيسيون: Stone, Daniel, Kenkel, Elizabeth J., Loprieno, Michelle A., Tanaka, Motoko, De Silva Feelixge, Harshana S., Kumar, Arjun J., Stensland, Laurence, Obenza, Willimark M., Wangari, Solomon, Ahrens, Chul Y., Murnane, Robert D., Peterson, Christopher W., Kiem, Hans-Peter, Huang, Meei-Li, Aubert, Martine, Hu, Shiu-Lok, Jerome, Keith R.
التنسيق: Artigo
اللغة:Inglês
منشور في: Mary Ann Liebert, Inc., publishers 2021
الموضوعات:
Research Articles
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020555/
https://ncbi.nlm.nih.gov/pubmed/32998579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2020.113
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