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Structure-function Analysis of Receptor-binding in Adeno-Associated Virus Serotype 6 (AAV-6)

Crystal structures of the AAV-6 capsid at 3 Å reveal a subunit fold homologous to other parvoviruses with greatest differences in two external loops. The electrostatic potential suggests that receptor-attachment is mediated by four residues: Arg(576), Lys(493), Lys(459) and Lys(531), defining a posi...

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Main Authors: Xie, Qing, Lerch, Thomas F., Meyer, Nancy L., Chapman, Michael S.
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185213/
https://ncbi.nlm.nih.gov/pubmed/21917284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2011.08.011
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