Adeno-Associated Virus (AAV) Serotype 9 Provides Global Cardiac Gene Transfer Superior to AAV1, AAV6, AAV7, and AAV8 in the Mouse and Rat

Heart disease is the leading cause of morbidity and mortality. Cardiac gene transfer may serve as a novel therapeutic approach. This investigation was undertaken to compare cardiac tropisms of adeno-associated virus (AAV) serotypes 1, 6, 7, 8, and 9. Neonatal mice were injected with 2.5 × 10(11) gen...

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מידע ביבליוגרפי
Main Authors: Bish, Lawrence T., Morine, Kevin, Sleeper, Meg M., Sanmiguel, Julio, Wu, Di, Gao, Guangping, Wilson, James M., Sweeney, H. Lee
פורמט: Artigo
שפה:Inglês
יצא לאור: Mary Ann Liebert, Inc. 2008
נושאים:
Scientific Papers
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940566/
https://ncbi.nlm.nih.gov/pubmed/18795839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2008.123
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