Effect of Nuclear Factor κB Inhibition on Serotype 9 Adeno-Associated Viral (AAV9) Minidystrophin Gene Transfer to the mdx Mouse

Gene therapy studies for Duchenne muscular dystrophy (DMD) have focused on viral vector-mediated gene transfer to provide therapeutic protein expression or treatment with drugs to limit dystrophic changes in muscle. The pathological activation of the nuclear factor (NF)-κB signaling pathway has emer...

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Hlavní autoři: Reay, Daniel P, Niizawa, Gabriela A, Watchko, Jon F, Daood, Molly, Reay, Ja’Nean C, Raggi, Eugene, Clemens, Paula R
Médium: Artigo
Jazyk:Inglês
Vydáno: ScholarOne 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356420/
https://ncbi.nlm.nih.gov/pubmed/22231732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2011.00404
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