Gene Transfer in Adeno-Associated Virus Seropositive Rhesus Macaques Following Rapamycin Treatment and Subcutaneous Delivery of AAV6, but Not Retargeted AAV6 Vectors

Adeno-associated virus (AAV) vectors such as AAV6, which shows tropism for primary human CD4(+) T cells in vitro, are being explored for delivery of anti-HIV therapeutic modalities in vivo. However, pre-existing immunity and sequestration in nontarget organs can significantly hinder their performanc...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther
Main Authors: Stone, Daniel, Kenkel, Elizabeth J., Loprieno, Michelle A., Tanaka, Motoko, De Silva Feelixge, Harshana S., Kumar, Arjun J., Stensland, Laurence, Obenza, Willimark M., Wangari, Solomon, Ahrens, Chul Y., Murnane, Robert D., Peterson, Christopher W., Kiem, Hans-Peter, Huang, Meei-Li, Aubert, Martine, Hu, Shiu-Lok, Jerome, Keith R.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8020555/
https://ncbi.nlm.nih.gov/pubmed/32998579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2020.113
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