Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine

The search for vaccines that protect from severe morbidity and mortality because of infection with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus that causes coronavirus disease 2019 (COVID‐19) is a race against the clock and the virus. Here we describe an amphiphilic imidaz...

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Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Jangra, Sonia, De Vrieze, Jana, Choi, Angela, Rathnasinghe, Raveen, Laghlali, Gabriel, Uvyn, Annemiek, Van Herck, Simon, Nuhn, Lutz, Deswarte, Kim, Zhong, Zifu, Sanders, Niek N., Lienenklaus, Stefan, David, Sunil A., Strohmeier, Shirin, Amanat, Fatima, Krammer, Florian, Hammad, Hamida, Lambrecht, Bart N., Coughlan, Lynda, García‐Sastre, Adolfo, De Geest, Bruno G., Schotsaert, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2021
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8014308/
https://ncbi.nlm.nih.gov/pubmed/33464672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202015362
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