Introduction of two prolines and removal of the polybasic cleavage site leads to optimal efficacy of a recombinant spike based SARS-CoV-2 vaccine in the mouse model

The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the prime target for vaccine development. The spike protein mediates both binding to host cells and membrane fusion and is also so far the only known viral target of neutralizing antibodies. Coro...

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Veröffentlicht in:bioRxiv
Hauptverfasser: Amanat, Fatima, Strohmeier, Shirin, Rathnasinghe, Raveen, Schotsaert, Michael, Coughlan, Lynda, García-Sastre, Adolfo, Krammer, Florian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7523111/
https://ncbi.nlm.nih.gov/pubmed/32995785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.09.16.300970
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