Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States and is primarily caused by cigarette smoking. Increased numbers of mucus-producing secretory (“goblet”) cells, defined as goblet cell metaplasia or hyperplasia (GCMH), contributes significantly to C...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Bodas, Manish, Moore, Andrew R., Subramaniyan, Bharathiraja, Georgescu, Constantin, Wren, Jonathan D., Freeman, Willard M., Brown, Brent R., Metcalf, Jordan P., Walters, Matthew S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2021
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8008804/
https://ncbi.nlm.nih.gov/pubmed/33444514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2020-0302OC
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