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The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways

Hox genes encode transcription factors controlling complex developmental processes in various organs. Little is known, however, about how HOX proteins control cell fate. Herein, we demonstrate that the goblet cell metaplasia observed in lung airways from Hoxa5(−/−) mice originates from the transdiff...

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Detalhes bibliográficos
Main Authors: Boucherat, Olivier, Chakir, Jamila, Jeannotte, Lucie
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3507293/
https://ncbi.nlm.nih.gov/pubmed/23213461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.20121701
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