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Notch signaling promotes airway mucous metaplasia and inhibits alveolar development

The airways are conduits that transport atmospheric oxygen to the distal alveolus. Normally, airway mucous cells are rare. However, diseases of the airway are often characterized by mucous metaplasia, in which there are dramatic increases in mucous cell numbers. As the Notch pathway is known to regu...

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Detalhes bibliográficos
Main Authors: Guseh, J. Sawalla, Bores, Sam A., Stanger, Ben Z., Zhou, Qiao, Anderson, William J., Melton, Douglas A., Rajagopal, Jayaraj
Formato: Artigo
Idioma:Inglês
Publicado em: Company of Biologists 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673763/
https://ncbi.nlm.nih.gov/pubmed/19369400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.029249
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