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The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways
Hox genes encode transcription factors controlling complex developmental processes in various organs. Little is known, however, about how HOX proteins control cell fate. Herein, we demonstrate that the goblet cell metaplasia observed in lung airways from Hoxa5(−/−) mice originates from the transdiff...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Company of Biologists
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3507293/ https://ncbi.nlm.nih.gov/pubmed/23213461 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.20121701 |
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