Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States and is primarily caused by cigarette smoking. Increased numbers of mucus-producing secretory (“goblet”) cells, defined as goblet cell metaplasia or hyperplasia (GCMH), contributes significantly to C...

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Dettagli Bibliografici
Pubblicato in:Am J Respir Cell Mol Biol
Autori principali: Bodas, Manish, Moore, Andrew R., Subramaniyan, Bharathiraja, Georgescu, Constantin, Wren, Jonathan D., Freeman, Willard M., Brown, Brent R., Metcalf, Jordan P., Walters, Matthew S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2021
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8008804/
https://ncbi.nlm.nih.gov/pubmed/33444514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2020-0302OC
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