The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms

Dermatan sulfate epimerase 1 (DS-epi1, EC 5.1.3.19) catalyzes the conversion of d-glucuronic acid to l-iduronic acid on the polymer level, a key step in the biosynthesis of the glycosaminoglycan dermatan sulfate. Here, we present the first crystal structure of the catalytic domains of DS-epi1, solve...

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Dettagli Bibliografici
Pubblicato in:Chem Sci
Autori principali: Hasan, Mahmudul, Khakzad, Hamed, Happonen, Lotta, Sundin, Anders, Unge, Johan, Mueller, Uwe, Malmström, Johan, Westergren-Thorsson, Gunilla, Malmström, Lars, Ellervik, Ulf, Malmström, Anders, Tykesson, Emil
Natura: Artigo
Lingua:Inglês
Pubblicazione: Royal Society of Chemistry 2020
Soggetti:
Chemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8006597/
https://ncbi.nlm.nih.gov/pubmed/33815739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc05971d
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