Dermatan sulfate epimerase 1 and dermatan 4-O-sulfotransferase 1 form complexes that generate long epimerized 4-O-sulfated blocks

During the biosynthesis of chondroitin/dermatan sulfate (CS/DS), a variable fraction of glucuronic acid is converted to iduronic acid through the activities of two epimerases, dermatan sulfate epimerases 1 (DS-epi1) and 2 (DS-epi2). Previous in vitro studies indicated that without association with o...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Tykesson, Emil, Hassinen, Antti, Zielinska, Katarzyna, Thelin, Martin A., Frati, Giacomo, Ellervik, Ulf, Westergren-Thorsson, Gunilla, Malmström, Anders, Kellokumpu, Sakari, Maccarana, Marco
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120188/
https://ncbi.nlm.nih.gov/pubmed/29976758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003875
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