The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher organisms

Dermatan sulfate epimerase 1 (DS-epi1, EC 5.1.3.19) catalyzes the conversion of d-glucuronic acid to l-iduronic acid on the polymer level, a key step in the biosynthesis of the glycosaminoglycan dermatan sulfate. Here, we present the first crystal structure of the catalytic domains of DS-epi1, solve...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Chem Sci
Main Authors: Hasan, Mahmudul, Khakzad, Hamed, Happonen, Lotta, Sundin, Anders, Unge, Johan, Mueller, Uwe, Malmström, Johan, Westergren-Thorsson, Gunilla, Malmström, Lars, Ellervik, Ulf, Malmström, Anders, Tykesson, Emil
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2020
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8006597/
https://ncbi.nlm.nih.gov/pubmed/33815739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc05971d
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker