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Deciphering the mode of action of the processive polysaccharide modifying enzyme dermatan sulfate epimerase 1 by hydrogen–deuterium exchange mass spectrometry

Distinct from template-directed biosynthesis of nucleic acids and proteins, the enzymatic synthesis of heterogeneous polysaccharides is a complex process that is difficult to study using common analytical tools. Therefore, the mode of action and processivity of those enzymes are largely unknown. Der...

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發表在:Chem Sci
Main Authors: Tykesson, Emil, Mao, Yang, Maccarana, Marco, Pu, Yi, Gao, Jinshan, Lin, Cheng, Zaia, Joseph, Westergren-Thorsson, Gunilla, Ellervik, Ulf, Malmström, Lars, Malmström, Anders
格式: Artigo
語言:Inglês
出版: Royal Society of Chemistry 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755500/
https://ncbi.nlm.nih.gov/pubmed/26900446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc03798k
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