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4-Benzylideneisoquinoline-1,3(2H,4H)-diones as tyrosyl DNA phosphodiesterase 2 (TDP2) inhibitors

Tyrosyl-DNA phosphodiesterase 2 (TDP2) repairs topoisomerase II (Top2) mediated DNA damages, including double-strand breaks (DSBs) that underpin the anticancer mechanism of clinical TOP2 poisons such as etoposide (ETP). Inhibition of TDP2 could sensitize cancer cells toward TOP2 poisons by increasin...

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Библиографические подробности
Опубликовано в: :Med Chem Res
Главные авторы: Senaweera, Sameera, He, Tianyu, Cui, Haixi, Aihara, Hideki, Wang, Zhengqiang
Формат: Artigo
Язык:Inglês
Опубликовано: 2020
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7993140/
https://ncbi.nlm.nih.gov/pubmed/33776385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00044-020-02662-w
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