Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure

Adenosine A(1) receptors (A(1)R) are a potential target for cardiac injury treatment due to their cardioprotective/antihypertrophic actions, but drug development has been hampered by on-target side effects such as bradycardia and altered renal hemodynamics. Biased agonism has emerged as an attractiv...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Rueda, Patricia, Merlin, Jon, Chimenti, Stefano, Feletou, Michel, Paysant, Jerome, White, Paul J., Christopoulos, Arthur, Sexton, Patrick M., Summers, Roger J., Charman, William N., May, Lauren T., Langmead, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7991592/
https://ncbi.nlm.nih.gov/pubmed/33776771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.628060
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