Only One Protomer Is Active in the Dimer of SARS 3C-like Proteinase

The severe acute respiratory syndrome coronavirus 3C-like protease has been proposed to be a key target for structurally based drug design against SARS. The enzyme exists as a mixture of dimer and monomer, and only the dimer was considered to be active. In this report, we have investigated, using mo...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Chen, Hao, Wei, Ping, Huang, Changkang, Tan, Lei, Liu, Ying, Lai, Luhua
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. 2006
Pynciau:
Enzyme Catalysis and Regulation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7990651/
https://ncbi.nlm.nih.gov/pubmed/16565086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M510745200
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