Maturation Mechanism of Severe Acute Respiratory Syndrome (SARS) Coronavirus 3C-like Proteinase

The 3C-like proteinase (3CL(pro)) of the severe acute respiratory syndrome (SARS) coronavirus plays a vital role in virus maturation and is proposed to be a key target for drug design against SARS. Various in vitro studies revealed that only the dimer of the matured 3CL(pro) is active. However, as t...

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Detalhes bibliográficos
Main Authors: Li, Chunmei, Qi, Yifei, Teng, Xin, Yang, Zongchang, Wei, Ping, Zhang, Changsheng, Tan, Lei, Zhou, Lu, Liu, Ying, Lai, Luhua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934678/
https://ncbi.nlm.nih.gov/pubmed/20489209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.095851
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