Biosynthesis, Purification, and Substrate Specificity of Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase

The 3C-like proteinase of severe acute respiratory syndrome (SARS) coronavirus has been proposed to be a key target for structural-based drug design against SARS. In order to understand the active form and the substrate specificity of the enzyme, we have cloned, expressed, and purified SARS 3C-like...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Fan, Keqiang, Wei, Ping, Feng, Qian, Chen, Sidi, Huang, Changkang, Ma, Liang, Lai, Bing, Pei, Jianfeng, Liu, Ying, Chen, Jianguo, Lai, Luhua
Format: Artigo
Sprache:Inglês
Veröffentlicht: ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. 2004
Schlagworte:
Enzyme Catalysis and Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980035/
https://ncbi.nlm.nih.gov/pubmed/14561748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M310875200
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